Combining causal model and focus group discussions experiences learned from a socio-anthropological research on the differing perceptions of caretakers and health professionals on children's health (Bolivia/Peru)

The paper discusses the utility of constructing causal models in focus groups. This was experienced as a complement to an in-depth ethnographic research on the differing perceptions of caretakers and health professionals on child's growth and development in Peru and Bolivia. The rational, advantages, difficulties and necessary adaptations of combining the two techniques are discussed on the basis of concrete examples. Authors conclude that the building of a causal model in a focus group session can be useful in comparing lay etiologies of diseases as perceived by different categories of caretakers and health professionals and in identifying specific health risks faced by children. Causal model building in a focus group can help renew discussions and participants'interest but its use is only justified when the study concerns the perception of the causality of a given phenomenon

Probing global aspects of a geometry by the self-force on a charge: Spherical thin-shell wormholes

The self-interaction for a static point charge in the space-time of a thin-shell wormhole constructed connecting two identical Schwarzschild geometries is calculated in a series expansion. The electrostatic self-force is evaluated numerically. It is found to be attractive towards the throat except for some values of the throat radius proximate to the value of the Schwarzschild horizon for which the force is repulsive or attractive depending on the position of the charge. The result differs from the self-force in the space-time of the Schwarzschild black hole, where it is always repulsive from the center. Although these wormhole and black hole geometries are locally indistinguishable, the different topologies of both backgrounds are manifested in the electrostatic field of a point charge.Comment: 17 pages, 4 figue

Fairness-Aware Ranking in Search & Recommendation Systems with Application to LinkedIn Talent Search

We present a framework for quantifying and mitigating algorithmic bias in mechanisms designed for ranking individuals, typically used as part of web-scale search and recommendation systems. We first propose complementary measures to quantify bias with respect to protected attributes such as gender and age. We then present algorithms for computing fairness-aware re-ranking of results. For a given search or recommendation task, our algorithms seek to achieve a desired distribution of top ranked results with respect to one or more protected attributes. We show that such a framework can be tailored to achieve fairness criteria such as equality of opportunity and demographic parity depending on the choice of the desired distribution. We evaluate the proposed algorithms via extensive simulations over different parameter choices, and study the effect of fairness-aware ranking on both bias and utility measures. We finally present the online A/B testing results from applying our framework towards representative ranking in LinkedIn Talent Search, and discuss the lessons learned in practice. Our approach resulted in tremendous improvement in the fairness metrics (nearly three fold increase in the number of search queries with representative results) without affecting the business metrics, which paved the way for deployment to 100% of LinkedIn Recruiter users worldwide. Ours is the first large-scale deployed framework for ensuring fairness in the hiring domain, with the potential positive impact for more than 630M LinkedIn members.Comment: This paper has been accepted for publication at ACM KDD 201

Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells

A systematic comparison of the protein synthesis patterns of cultured normal and transformed human fibroblasts and epithelial cells, using two-dimensional gel protein analysis combined with computerized imaging and data acquisition, identified a 90-kD protein (SSP 5714) as one of the most striking downregulated markers typical of the transformed state. Using the information stored in the comprehensive human cellular protein database, we found this protein strongly expressed in several fetal tissues and one of them, epidermis, served as a source for preparative two-dimensional gel electrophoresis. Partial amino acid sequences were generated from peptides obtained by in situ digestion of the electroblotted protein. These sequences identified the marker protein as gelsolin, a finding that was confirmed by two-dimensional immunoblotting of human MRC-5 fibroblast proteins using specific antibodies and by coelectrophoresis with purified human gelsolin. These results suggest that an important regulatory protein of the microfilament system may play a role in defining the phenotype of transformed human fibroblast and epithelial cells in culture

12CO and 13CO J=3-2 observations toward N11 in the Large Magellanic Cloud

After 30 Doradus, N11 is the second largest and brightest nebula in the LMC. This large nebula has several OB associations with bright nebulae at its surroundings. N11 was previously mapped at the lowest rotational transitions of $^{12}$CO (J=1--0 and 2--1), and in some particular regions pointings of the $^{13}$CO J=1--0 and 2--1 lines were also performed. Using ASTE we mapped the whole extension of the N11 nebula in the $^{12}$CO J=3--2 line, and three sub-regions in the $^{13}$CO J=3--2 line. The regions mapped in the $^{13}$CO J=3--2 were selected based on that they may be exposed to the radiation at different ways: a region lying over the nebula related to the OB association LH10 (N11B), another one that it is associated with the southern part of the nebula related to the OB association LH13 (N11D), and finally a farther area at the southwest without any embedded OB association (N11I). We found that the morphology of the molecular clouds lying in each region shows some signatures that could be explained by the expansion of the nebulae and the action of the radiation. Fragmentation generated in a molecular shell due to the expansion of the N11 nebula is suggested. The integrated line ratios $^{12}$CO/$^{13}$CO show evidences of selective photodissociation of the $^{13}$CO, and probably other mechanisms such as chemical fractionation. The CO contribution to the continuum at 870 $\mu$m was directly derived. The distribution of the integrated line ratios $^{12}$CO J=3--2/2--1 show hints of stellar feedback in N11B and N11D. The ratio between the virial and LTE mass (M$_{\rm vir}$/M$_{\rm LTE}$) is higher than unity in all analyzed molecular clumps, which suggests that the clumps are not gravitationally bounded and may be supported by external pressure. A non-LTE analysis suggests that we are mapping gas with densities about a few 10$^{3}$ cm$^{-3}$.Comment: Accepted to be published in A&A. Figures were degrade

Synthesis of the nuclear protein cyclin in growing, senescent and morphologically transformed human skin fibroblasts

AbstractQuantitative two-dimensional gel electrophoretic analysis (IEF) of the nuclear polypeptide cyclin in normal human skin biopsies, growing and senescent fibroblasts and morphologically transformed skin fibroblasts (limited life span) has revealed a direct correlation between the levels of this protein and the proliferative state of the cells. These results strengthen the notion that cyclin may be a key component of the pathway(s) that control cell proliferation